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Role of the Extracellular Loops of G Protein-Coupled Receptors in Ligand Recognition: A Molecular Modeling Study of the Human P2Y(1) Receptor

The P2Y(1) receptor is a G protein-coupled receptor (GPCR) and is stimulated by extracellular ADP and ATP. Site-directed mutagenesis of the three extracellular loops (ELs) of the human P2Y(1) receptor indicates the existence of two essential disulfide bridges (Cys124 in EL1 and Cys202 in EL2; Cys42...

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Publicat a:Biochemistry
Autors principals: Moro, Stefano, Hoffmann, Carsten, Jacobson, Kenneth A.
Format: Artigo
Idioma:Inglês
Publicat: 1999
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4969012/
https://ncbi.nlm.nih.gov/pubmed/10090736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi982369v
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