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Differential Regulation of Bcl-x(L) Gene Expression by Corticosterone, Progesterone and Retinoic Acid
Corticosterone (CT), progesterone (PG), and retinoic acid (RA) are capable of inhibiting Doxorubicin (Dox) from inducing apoptosis in rat cardiomyocytes. Mechanistically, CT, PG and RA induce increases of Bcl-x(L) protein and mRNA, and activate a 3.2 kb bcl-x gene promoter. CT and RA, but not PG ind...
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| Publicado no: | J Biochem Mol Toxicol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4969002/ https://ncbi.nlm.nih.gov/pubmed/26915917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbt.21795 |
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