Regulated high level expression of a human gamma-globin gene introduced into erythroid cells by an adeno-associated virus vector.

Gene therapy of severe hemoglobinopathies will require high-level expression of a transferred globin gene in erythroid cells. Distant regulatory elements flanking the beta-globin gene cluster, the locus control region, are needed for appropriate expression. We have explored the use of a human parvov...

Cijeli opis

Bibliografski detalji

Izdano u:	Proc Natl Acad Sci U S A
Glavni autori:	Walsh, C E, Liu, J M, Xiao, X, Young, N S, Nienhuis, A W, Samulski, R J
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 1992
Teme:	Research Article
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49685/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1323131/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.15.7257
Oznake:	Dodaj oznaku Bez oznaka, Budi prvi tko označuje ovaj zapis!