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Quantitation and pharmacokinetic modeling of therapeutic antibody quality attributes in human studies

A thorough understanding of drug metabolism and disposition can aid in the assessment of efficacy and safety. However, analytical methods used in pharmacokinetics (PK) studies of protein therapeutics are usually based on ELISA, and therefore can provide a limited perspective on the quality of the dr...

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Bibliografische gegevens
Gepubliceerd in:MAbs
Hoofdauteurs: Li, Yinyin, Monine, Michael, Huang, Yu, Swann, Patrick, Nestorov, Ivan, Lyubarskaya, Yelena
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2016
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968108/
https://ncbi.nlm.nih.gov/pubmed/27216574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1186322
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