Activation of lysosomal P2X4 by ATP transported into lysosomes via VNUT/SLC17A9 using V‐ATPase generated voltage gradient as the driving force

KEY POINTS: SLC17A9 proteins function as a lysosomal ATP transporter responsible for lysosomal ATP accumulation. P2X4 receptors act as lysosomal ion channels activated by luminal ATP. SLC17A9‐mediated ATP transport across the lysosomal membrane is suppressed by Bafilomycin A1, the V‐ATPase inhibitor...

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Bibliographic Details
Published in:J Physiol
Main Authors: Zhong, Xi Zoë, Cao, Qi, Sun, Xue, Dong, Xian‐Ping
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2016
Subjects:
Molecular and cellular
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967729/
https://ncbi.nlm.nih.gov/pubmed/27477609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP271893
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