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Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases

Mapping the molecular circuits that are perturbed by genetic variants underlying complex traits and diseases remains a great challenge. We present a comprehensive resource of 394 cell type and tissue-specific gene regulatory networks for human, each specifying the genome-wide connectivity between tr...

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Detalhes bibliográficos
Publicado no:Nat Methods
Main Authors: Marbach, Daniel, Lamparter, David, Quon, Gerald, Kellis, Manolis, Kutalik, Zoltán, Bergmann, Sven
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967716/
https://ncbi.nlm.nih.gov/pubmed/26950747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.3799
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