Overexpressing corticotropin-releasing hormone (CRH) in the primate amygdala increases anxious temperament and alters its neural circuit

BACKGROUND: Nonhuman primate models are critical for understanding mechanisms underlying human psychopathology. We established a non-human primate model of anxious temperament (AT) for studying the early-life risk to develop anxiety and depression. Studies have identified the central nucleus of the...

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Vydáno v:Biol Psychiatry
Hlavní autoři: Kalin, Ned H, Fox, Andrew S, Kovner, Rothem, Riedel, Marissa K, Fekete, Eva M, Roseboom, Patrick H, Tromp, Do P M, Grabow, Benjamin P, Olsen, Miles E, Brodsky, Ethan K, McFarlin, Daniel R., Alexander, Andrew L, Emborg, Marina E, Block, Walter F, Fudge, Julie L, Oler, Jonathan A
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967405/
https://ncbi.nlm.nih.gov/pubmed/27016385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2016.01.010
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