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Site-directed mutants of human RECQ1 reveal functional importance of the zinc binding domain
RecQ helicases are a highly conserved family of ATP-dependent DNA-unwinding enzymes with key roles in DNA replication and repair in all kingdoms of life. The RECQ1 gene encodes the most abundant RecQ homolog in humans. Mutations in RECQ1 significantly increase breast cancer susceptibility. We engine...
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| Publicado no: | Mutat Res |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4967042/ https://ncbi.nlm.nih.gov/pubmed/27248010 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2016.05.005 |
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