Adjacent Codons Act in Concert to Modulate Translation Efficiency in Yeast

Translation elongation efficiency is largely thought of as the sum of decoding efficiencies for individual codons. Here, we find that adjacent codon pairs modulate translation efficiency. Deploying an approach in Saccharomyces cerevisiae that scored the expression of over 35,000 GFP variants in whic...

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Udgivet i:Cell
Main Authors: Gamble, Caitlin E., Brule, Christina E., Dean, Kimberly M., Fields, Stanley, Grayhack, Elizabeth J.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967012/
https://ncbi.nlm.nih.gov/pubmed/27374328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.05.070
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