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Hsp90 induces increased genomic instability toward DNA-damaging agents by tuning down RAD53 transcription
It is well documented that elevated body temperature causes tumors to regress upon radiotherapy. However, how hyperthermia induces DNA damage sensitivity is not clear. We show that a transient heat shock and particularly the concomitant induction of Hsp90 lead to increased genomic instability under...
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| Udgivet i: | Mol Biol Cell |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The American Society for Cell Biology
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4966986/ https://ncbi.nlm.nih.gov/pubmed/27307581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-12-0867 |
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