A distinct cytoplasmic domain of CD2 regulates ligand avidity and T-cell responsiveness to antigen.

The T-cell glycoprotein CD2 not only contributes to intercellular adhesion but also plays a direct role in T-cell activation. Here we demonstrate that the interaction of CD2 with its ligand lymphocyte function-associated antigen 3 (CD58) is regulated by T-cell receptor-CD3 signaling. T-cell receptor...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Hahn, W C, Rosenstein, Y, Calvo, V, Burakoff, S J, Bierer, B E
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49669/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1353888/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.15.7179
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