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Combining phage display with de novo protein sequencing for reverse engineering of monoclonal antibodies
The enormous diversity created by gene recombination and somatic hypermutation makes de novo protein sequencing of monoclonal antibodies a uniquely challenging problem. Modern mass spectrometry-based sequencing will rarely, if ever, provide a single unambiguous sequence for the variable domains. A m...
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| Publicado no: | MAbs |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4966834/ https://ncbi.nlm.nih.gov/pubmed/26852694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1145865 |
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