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The application of mathematical modelling to the design of bispecific monoclonal antibodies

Targeting multiple receptors with bispecific antibodies is a novel approach that may prevent the development of resistance to cancer treatments. Despite the initial promise, full clinical benefit of this technology has yet to be realized. We hypothesized that in order to optimally exploit bispecific...

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Publicat a:MAbs
Autors principals: van Steeg, Tamara J., Bergmann, Kirsten Riber, Dimasi, Nazzareno, Sachsenmeier, Kris F., Agoram, Balaji
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966826/
https://ncbi.nlm.nih.gov/pubmed/26910134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1141160
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