Safety evaluation of intravenously administered mono-thioated aptamer against E-selectin in mice

The medical applications of aptamers have recently emerged. We developed an antagonistic thioaptamer (ESTA) against E-selectin. Previously, we showed that a single injection of ESTA at a dose of 100 μg inhibits breast cancer metastasis in mice through the functional blockade of E-selectin. In the pr...

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Veröffentlicht in:Toxicol Appl Pharmacol
Hauptverfasser: Kang, Shin-Ae, Tsolmon, Bilegtsaikhan, Mann, Aman, Zheng, Wei, Zhao, Lichao, Zhao, Yan Daniel, Volk, David E., Lokesh, Ganesh L.-R., Morris, Lynsie, Gupta, Vineet, Razaq, Wajeeha, Rui, Hallgeir, Suh, Stephen K., Gorenstein, David G., Tanaka, Takemi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966538/
https://ncbi.nlm.nih.gov/pubmed/26048585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2015.05.011
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