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BRCA1 loses the ring but lords over resistance
Germline breast cancer 1 (BRCA1) variants are associated with a high risk of breast and ovarian cancers. Many BRCA1-mediated cancers are initially responsive to platinum-based therapy; however, resistance commonly develops. The BRCA1(185delAG) mutation is common in the Ashkenazi Jewish population an...
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| Publicat a: | J Clin Invest |
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| Autor principal: | |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Clinical Investigation
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4966308/ https://ncbi.nlm.nih.gov/pubmed/27454288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI89209 |
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