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Diabetes Stimulates Osteoclastogenesis by Acidosis-Induced Activation of Transient Receptor Potential Cation Channels

Patients with type 1 diabetes have lower bone mineral density and higher risk of fractures. The role of osteoblasts in diabetes-related osteoporosis is well acknowledged whereas the role of osteoclasts (OCLs) is still unclear. We hypothesize that OCLs participate in pathological bone remodeling. We...

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Опубликовано в: :Sci Rep
Главные авторы: Reni, Carlotta, Mangialardi, Giuseppe, Meloni, Marco, Madeddu, Paolo
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965751/
https://ncbi.nlm.nih.gov/pubmed/27468810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30639
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