MYB Promotes Desmoplasia in Pancreatic Cancer through Direct Transcriptional Up-regulation and Cooperative Action of Sonic Hedgehog and Adrenomedullin

Extensive desmoplasia is a prominent pathological characteristic of pancreatic cancer (PC) that not only impacts tumor development, but therapeutic outcome as well. Recently, we demonstrated a novel role of MYB, an oncogenic transcription factor, in PC growth and metastasis. Here we studied its effe...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Bhardwaj, Arun, Srivastava, Sanjeev K., Singh, Seema, Tyagi, Nikhil, Arora, Sumit, Carter, James E., Khushman, Moh'd, Singh, Ajay P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965574/
https://ncbi.nlm.nih.gov/pubmed/27246849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.732651
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