The Role of Active Site Flexible Loops in Catalysis and of Zinc in Conformational Stability of Bacillus cereus 569/H/9 β-Lactamase

Metallo-β-lactamases catalyze the hydrolysis of most β-lactam antibiotics and hence represent a major clinical concern. The development of inhibitors for these enzymes is complicated by the diversity and flexibility of their substrate-binding sites, motivating research into their structure and funct...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Montagner, Caroline, Nigen, Michaël, Jacquin, Olivier, Willet, Nicolas, Dumoulin, Mireille, Karsisiotis, Andreas Ioannis, Roberts, Gordon C. K., Damblon, Christian, Redfield, Christina, Matagne, André
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965562/
https://ncbi.nlm.nih.gov/pubmed/27235401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.719005
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