B-Cell Dysregulation in Crohn's Disease Is Partially Restored with Infliximab Therapy

BACKGROUND: B-cell depletion can improve a variety of chronic inflammatory diseases, but does not appear beneficial for patients with Crohn’s disease. OBJECTIVE: To elucidate the involvement of B cells in Crohn’s disease, we here performed an ‘in depth’ analysis of intestinal and blood B-cells in th...

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Pubblicato in:PLoS One
Autori principali: Timmermans, Wilhelmina M. C., van Laar, Jan A. M., van der Houwen, Tim B., Kamphuis, Lieke S. J., Bartol, Sophinus J. W., Lam, King H., Ouwendijk, Rob J., Sparrow, Miles P., Gibson, Peter R., van Hagen, P. Martin, van Zelm, Menno C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965034/
https://ncbi.nlm.nih.gov/pubmed/27468085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160103
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