SCISSOR—Spinal Cord Injury Study on Small molecule-derived Rho inhibition: a clinical study protocol

INTRODUCTION: The approved analgesic and anti-inflammatory drugs ibuprofen and indometacin block the small GTPase RhoA, a key enzyme that impedes axonal sprouting after axonal damage. Inhibition of the Rho pathway in a central nervous system-effective manner requires higher dosages compared with ort...

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Vydáno v:BMJ Open
Hlavní autoři: Kopp, Marcel A, Liebscher, Thomas, Watzlawick, Ralf, Martus, Peter, Laufer, Stefan, Blex, Christian, Schindler, Ralf, Jungehulsing, Gerhard J, Knüppel, Sven, Kreutzträger, Martin, Ekkernkamp, Axel, Dirnagl, Ulrich, Strittmatter, Stephen M, Niedeggen, Andreas, Schwab, Jan M
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2016
Témata:
Neurology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4964175/
https://ncbi.nlm.nih.gov/pubmed/27466236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2015-010651
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