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Selected heterozygosity at cis-regulatory sequences increases the expression homogeneity of a cell population in humans
BACKGROUND: Examples of heterozygote advantage in humans are scarce and limited to protein-coding sequences. Here, we attempt a genome-wide functional inference of advantageous heterozygosity at cis-regulatory regions. RESULTS: The single-nucleotide polymorphisms bearing the signatures of balancing...
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| Publicado no: | Genome Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4964047/ https://ncbi.nlm.nih.gov/pubmed/27468897 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-1027-8 |
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