Production of functional, stable, unmutated recombinant human papillomavirus E6 oncoprotein: implications for HPV-tumor diagnosis and therapy

BACKGROUND: High-risk human papillomaviruses (HR-HPVs) types 16 and 18 are the main etiological agents of cervical cancer, with more than 550,000 new cases each year worldwide. HPVs are also associated with other ano-genital and head-and-neck tumors. The HR-HPV E6 and E7 oncoproteins are responsible...

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Bibliographic Details
Published in:J Transl Med
Main Authors: Illiano, Elena, Demurtas, Olivia Costantina, Massa, Silvia, Di Bonito, Paola, Consalvi, Valerio, Chiaraluce, Roberta, Zanotto, Carlo, De Giuli Morghen, Carlo, Radaelli, Antonia, Venuti, Aldo, Franconi, Rosella
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4963926/
https://ncbi.nlm.nih.gov/pubmed/27465494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-0978-6
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