Interaction between TNF and BmooMP-Alpha-I, a Zinc Metalloprotease Derived from Bothrops moojeni Snake Venom, Promotes Direct Proteolysis of This Cytokine: Molecular Modeling and Docking at a Glance

Tumor necrosis factor (TNF) is a major cytokine in inflammatory processes and its deregulation plays a pivotal role in several diseases. Here, we report that a zinc metalloprotease extracted from Bothrops moojeni venom (BmooMP-alpha-I) inhibits TNF directly by promoting its degradation. This inhibit...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Toxins (Basel)
Main Authors: Silva, Maraisa Cristina, Lopes Silva, Tamires, Silva, Murilo Vieira, Mota, Caroline Martins, Santiago, Fernanda Maria, Fonseca, Kelly Cortes, Oliveira, Fábio, Mineo, Tiago Wilson Patriarca, Mineo, José Roberto
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI 2016
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4963855/
https://ncbi.nlm.nih.gov/pubmed/27447669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins8070223
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