Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA.
It has been previously shown both in vivo and in vitro that DNA synthesis past an oxidatively damaged form of guanine, 7,8-dihydro-8-oxoguanine (8-oxoG), can result in the misincorporation of adenine (A) opposite the 8-oxodG. In this study we show that MutY glycosylase is active on a site-specific,...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1992
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49637/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1495996/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.15.7022 |
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