Mesenchymal tumors can derive from Ng2/Cspg4 expressing pericytes with β-catenin modulating the neoplastic phenotype

The cell of origin for most mesenchymal tumors is unclear. One cell type that contributes to this lineages is the pericyte, a cell expressing Ng2/Cspg4. Using lineage tracing, we demonstrated that bone and soft tissue sarcomas driven by the deletion of the Trp53 tumor suppressor, or desmoid tumors d...

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Publicat a:Cell Rep
Autors principals: Sato, Shingo, Tang, Yuning J, Wei, Qingxia, Hirata, Makoto, Weng, Angela, Han, Ilkyu, Okawa, Atsushi, Takeda, Shu, Whetstone, Heather, Nadesan, Puvindran, Kirsch, David G., Wunder, Jay S., Alman, Benjamin A.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4963269/
https://ncbi.nlm.nih.gov/pubmed/27425618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.06.058
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