The RAS-Binding Domain of Human BRAF Protein Serine/Threonine Kinase Exhibits Allosteric Conformational Changes upon Binding HRAS

RAS binding is a critical step in the activation of BRAF protein serine/threonine kinase and stimulation of the mitogen-activated protein kinase signaling pathway. Mutations in both RAS and BRAF are associated with many human cancers. Here, we report the solution nuclear magnetic resonance (NMR) and...

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Bibliographic Details
Published in:Structure
Main Authors: Aramini, James M., Vorobiev, Sergey M., Tuberty, Lynda M., Janjua, Haleema, Campbell, Elliot T., Seetharaman, Jayaraman, Su, Min, Huang, Yuanpeng J., Acton, Thomas B., Xiao, Rong, Tong, Liang, Montelione, Gaetano T.
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4963008/
https://ncbi.nlm.nih.gov/pubmed/26165597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.06.003
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