A Mutation in the 16S rRNA Decoding Region Attenuates the Virulence of Mycobacterium tuberculosis

Mycobacterium tuberculosis contains a single rRNA operon that encodes targets for antituberculosis agents, including kanamycin. To date, only four mutations in the kanamycin binding sites of 16S rRNA have been reported in kanamycin-resistant clinical isolates. We hypothesized that another mutation(s...

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發表在:Infect Immun
Main Authors: Watanabe, Shinya, Matsumura, Kazunori, Iwai, Hiroki, Funatogawa, Keiji, Haishima, Yuji, Fukui, Chie, Okumura, Kayo, Kato-Miyazawa, Masako, Hashimoto, Masahito, Teramoto, Kanae, Kirikae, Fumiko, Miyoshi-Akiyama, Tohru, Kirikae, Teruo
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2016
主題:
Bacterial Infections
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4962622/
https://ncbi.nlm.nih.gov/pubmed/27245411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00417-16
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