Multiple capsid-stabilizing interactions revealed in a high-resolution structure of an emerging picornavirus causing neonatal sepsis

The poorly studied picornavirus, human parechovirus 3 (HPeV3) causes neonatal sepsis with no therapies available. Our 4.3-Å resolution structure of HPeV3 on its own and at 15 Å resolution in complex with human monoclonal antibody Fabs demonstrates the expected picornavirus capsid structure with thre...

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Publicado no:Nat Commun
Main Authors: Shakeel, Shabih, Westerhuis, Brenda M., Domanska, Ausra, Koning, Roman I., Matadeen, Rishi, Koster, Abraham J., Bakker, Arjen Q., Beaumont, Tim, Wolthers, Katja C., Butcher, Sarah J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961769/
https://ncbi.nlm.nih.gov/pubmed/27435188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11387
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