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Chemical modification of Glu-953 of the alpha chain of Na+,K(+)-ATPase associated with inactivation of cation occlusion.

We have investigated the role, number, and identity of glutamate (or aspartate) residues involved in cation occlusion on Na+, K(+)-ATPase, using the carboxyl reagent N,N'-dicyclohexylcarbodiimide (DCCD). Extensive use is made of selectively trypsinized Na+,K(+)-ATPase--the so-called "19-kDa membrane...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Goldshleger, R, Tal, D M, Moorman, J, Stein, W D, Karlish, S J
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1992
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49614/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1353883/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.15.6911
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