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Structural basis for sulfation-dependent self-glycan recognition by the human immune-inhibitory receptor Siglec-8
Siglec-8 is a human immune-inhibitory receptor that, when engaged by specific self-glycans, triggers eosinophil apoptosis and inhibits mast cell degranulation, providing an endogenous mechanism to down-regulate immune responses of these central inflammatory effector cells. Here we used solution NMR...
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| Gepubliceerd in: | Proc Natl Acad Sci U S A |
|---|---|
| Hoofdauteurs: | , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4961179/ https://ncbi.nlm.nih.gov/pubmed/27357658 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1602214113 |
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