Unfolding the mechanism of the AAA+ unfoldase VAT by a combined cryo-EM, solution NMR study

The AAA+ (ATPases associated with a variety of cellular activities) enzymes play critical roles in a variety of homeostatic processes in all kingdoms of life. Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), the archaeal homolog of the ubiquitous AAA+ protein Cdc48/p97, func...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Huang, Rui, Ripstein, Zev A., Augustyniak, Rafal, Lazniewski, Michal, Ginalski, Krzysztof, Kay, Lewis E., Rubinstein, John L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961139/
https://ncbi.nlm.nih.gov/pubmed/27402735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603980113
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