Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose

Vaccines have had broad medical impact, but existing vaccine technologies and production methods are limited in their ability to respond rapidly to evolving and emerging pathogens, or sudden outbreaks. Here, we develop a rapid-response, fully synthetic, single-dose, adjuvant-free dendrimer nanoparti...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Chahal, Jasdave S., Khan, Omar F., Cooper, Christopher L., McPartlan, Justine S., Tsosie, Jonathan K., Tilley, Lucas D., Sidik, Saima M., Lourido, Sebastian, Langer, Robert, Bavari, Sina, Ploegh, Hidde L., Anderson, Daniel G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961123/
https://ncbi.nlm.nih.gov/pubmed/27382155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600299113
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