Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose

Vaccines have had broad medical impact, but existing vaccine technologies and production methods are limited in their ability to respond rapidly to evolving and emerging pathogens, or sudden outbreaks. Here, we develop a rapid-response, fully synthetic, single-dose, adjuvant-free dendrimer nanoparti...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Chahal, Jasdave S., Khan, Omar F., Cooper, Christopher L., McPartlan, Justine S., Tsosie, Jonathan K., Tilley, Lucas D., Sidik, Saima M., Lourido, Sebastian, Langer, Robert, Bavari, Sina, Ploegh, Hidde L., Anderson, Daniel G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961123/
https://ncbi.nlm.nih.gov/pubmed/27382155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600299113
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