Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose

Vaccines have had broad medical impact, but existing vaccine technologies and production methods are limited in their ability to respond rapidly to evolving and emerging pathogens, or sudden outbreaks. Here, we develop a rapid-response, fully synthetic, single-dose, adjuvant-free dendrimer nanoparti...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Chahal, Jasdave S., Khan, Omar F., Cooper, Christopher L., McPartlan, Justine S., Tsosie, Jonathan K., Tilley, Lucas D., Sidik, Saima M., Lourido, Sebastian, Langer, Robert, Bavari, Sina, Ploegh, Hidde L., Anderson, Daniel G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2016
Ábhair:
PNAS Plus
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961123/
https://ncbi.nlm.nih.gov/pubmed/27382155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600299113
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