Crx(Rdy) Cat: A Large Animal Model for CRX-Associated Leber Congenital Amaurosis

PURPOSE: Mutations in the retinal transcription factor cone-rod homeobox (CRX) gene result in severe dominant retinopathies. A large animal model, the Rdy cat, carrying a spontaneous frameshift mutation in Crx, was reported previously. The present study aimed to further understand pathogenesis in th...

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Bibliographic Details
Published in:Invest Ophthalmol Vis Sci
Main Authors: Occelli, Laurence M., Tran, Nicholas M., Narfström, Kristina, Chen, Shiming, Petersen-Jones, Simon M.
Format: Artigo
Language:Inglês
Published: The Association for Research in Vision and Ophthalmology 2016
Subjects:
Retinal Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4960999/
https://ncbi.nlm.nih.gov/pubmed/27427859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.16-19444
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