The anti-sigma factor RsrA responds to oxidative stress by reburying its hydrophobic core

Redox-regulated effector systems that counteract oxidative stress are essential for all forms of life. Here we uncover a new paradigm for sensing oxidative stress centred on the hydrophobic core of a sensor protein. RsrA is an archetypal zinc-binding anti-sigma factor that responds to disulfide stre...

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Publicat a:Nat Commun
Autors principals: Rajasekar, Karthik V., Zdanowski, Konrad, Yan, Jun, Hopper, Jonathan T. S., Francis, Marie-Louise R., Seepersad, Colin, Sharp, Connor, Pecqueur, Ludovic, Werner, Jörn M., Robinson, Carol V., Mohammed, Shabaz, Potts, Jennifer R., Kleanthous, Colin
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4960319/
https://ncbi.nlm.nih.gov/pubmed/27432510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12194
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