A Novel Association of Neuropilin-1 and MUC1 in Pancreatic Ductal Adenocarcinoma: Role in Induction of VEGF Signaling and Angiogenesis

We report that MUC1, a transmembrane glycoprotein that is overexpressed in >80% of pancreatic ductal adenocarcinoma (PDA) induced a pro-angiogenic tumor microenvironment by increasing the levels of neuropilin-1 (NRP1, a co-receptor of VEGF) and its ligand, VEGF. Expression of tumor-associated MUC...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Zhou, Ru, Curry, Jennifer M, Roy, Lopamudra Das, Grover, Priyanka, Haider, Jamil, Moore, Laura J., Wu, Shu-ta, Kamesh, Anishaa, Yazdanifar, Mahboubeh, Ahrens, William A., Leung, TinChung, Mukherjee, Pinku
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4960005/
https://ncbi.nlm.nih.gov/pubmed/26804176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.516
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados