Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway

Group 3 innate lymphoid cells (ILC3s) expressing the transcription factor (TF) RORγt are important for the defense and homeostasis of host intestinal tissues. The zinc finger TF Ikaros encoded by Ikzf1 is essential for RORγt(+) fetal lymphoid tissue inducer (LTi) cell development and lymphoid organo...

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Publicat a:Immunity
Autors principals: Li, Shiyang, Heller, Jennifer J., Bostick, John W., Lee, Aileen, Schjerven, Hilde, Kastner, Philippe, Chan, Susan, Chen, Zongming E., Zhou, Liang
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959810/
https://ncbi.nlm.nih.gov/pubmed/27438771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.06.027
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