Mast cells positive to tryptase, endothelial cells positive to protease-activated receptor-2, and microvascular density correlate among themselves in hepatocellular carcinoma patients who have undergone surgery

BACKGROUND: Mast cells (MCs) can stimulate angiogenesis, releasing several proangiogenic cytokines stored in their cytoplasm. In particular MCs can release tryptase, a potent in vivo and in vitro proangiogenic factor via proteinase-activated receptor-2 (PAR-2) activation and mitogen-activated protei...

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Veröffentlicht in:Onco Targets Ther
Hauptverfasser: Ammendola, Michele, Sacco, Rosario, Sammarco, Giuseppe, Piardi, Tullio, Zuccalà, Valeria, Patruno, Rosa, Zullo, Alessandra, Zizzo, Nicola, Nardo, Bruno, Marech, Ilaria, Crovace, Alberto, Gadaleta, Cosmo Damiano, Pessaux, Patrick, Ranieri, Girolamo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2016
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959580/
https://ncbi.nlm.nih.gov/pubmed/27499640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S105368
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