Metabolic Engineering of Mortierella alpina for Enhanced Arachidonic Acid Production through the NADPH-Supplying Strategy

NADPH is known to be a key cofactor required for fatty acid synthesis and desaturation. Various enzymatic reactions can generate NADPH. To determine the effect of NADPH sources on lipogenesis, glucose-6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (PGD), isocitrate dehydrogenase...

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發表在:Appl Environ Microbiol
Main Authors: Hao, Guangfei, Chen, Haiqin, Gu, Zhennan, Zhang, Hao, Chen, Wei, Chen, Yong Q.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2016
主題:
Biotechnology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959234/
https://ncbi.nlm.nih.gov/pubmed/27016571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00572-16
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