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Autophagy Inhibition Delays Early but Not Late-Stage Metastatic Disease

The autophagy pathway has been recognized as a mechanism of survival and therapy resistance in cancer, yet the extent of autophagy’s function in metastatic progression is still unclear. Therefore, we used murine models of metastatic cancer to investigate the effect of autophagy modulation on metasta...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Barnard, Rebecca A., Regan, Daniel P., Hansen, Ryan J., Maycotte, Paola, Thorburn, Andrew, Gustafson, Daniel L.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959099/
https://ncbi.nlm.nih.gov/pubmed/27231155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.233908
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