Allosteric Activation of Ubiquitin-Specific Proteases by β-propeller Proteins UAF1 and WDR20

Ubiquitin-specific proteases (USPs) constitute the largest family of deubiquitinating enzymes, whose catalytic competency is often modulated by their binding partners through unknown mechanisms. Here we report a series of crystallographic and biochemical analyses of an evolutionarily conserved deubi...

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Udgivet i:Mol Cell
Main Authors: Li, Heng, Lim, Kah Suan, Kim, Hyungjin, Hinds, Thomas R., Jo, Ukhyun, Mao, Haibin, Weller, Caroline E., Sun, Ji, Chatterjee, Champak, D’Andrea, Alan D., Zheng, Ning
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958508/
https://ncbi.nlm.nih.gov/pubmed/27373336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.05.031
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