Engineering of Kuma030: A Gliadin Peptidase That Rapidly Degrades Immunogenic Gliadin Peptides in Gastric Conditions

Celiac disease is characterized by intestinal inflammation triggered by gliadin, a component of dietary gluten. Oral administration of proteases that can rapidly degrade gliadin in the gastric compartment has been proposed as a treatment for celiac disease; however, no protease has been shown to spe...

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Veröffentlicht in:J Am Chem Soc
Hauptverfasser: Wolf, Clancey, Siegel, Justin B., Tinberg, Christine, Camarca, Alessandra, Gianfrani, Carmen, Paski, Shirley, Guan, Rongjin, Montelione, Gaetano, Baker, David, Pultz, Ingrid S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958374/
https://ncbi.nlm.nih.gov/pubmed/26374198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b08325
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