Mice with missense and nonsense NF1 mutations display divergent phenotypes compared with human neurofibromatosis type I

Neurofibromatosis type 1 (NF1) is a common genetic disorder characterized by the occurrence of nerve sheath tumors and considerable clinical heterogeneity. Some translational studies have been limited by the lack of animal models available for assessing patient-specific mutations. In order to test t...

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Detalles Bibliográficos
Publicado en:Dis Model Mech
Main Authors: Li, Kairong, Turner, Ashley N., Chen, Min, Brosius, Stephanie N., Schoeb, Trenton R., Messiaen, Ludwine M., Bedwell, David M., Zinn, Kurt R., Anastasaki, Corina, Gutmann, David H., Korf, Bruce R., Kesterson, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado: The Company of Biologists Ltd 2016
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958313/
https://ncbi.nlm.nih.gov/pubmed/27482814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.025783
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