Direct targeting of β-catenin by a small molecule stimulates proteasomal degradation and suppresses oncogenic Wnt/β-catenin signaling

The Wnt/β-catenin signaling pathway plays a major role in tissue homeostasis, and its dysregulation can lead to various human diseases. Aberrant activation of β-catenin is oncogenic and is a critical driver in the development and progression of human cancers. Despite the significant potential of tar...

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Publicat a:Cell Rep
Autors principals: Hwang, So-Young, Deng, Xianming, Byun, Sanguine, Lee, Chan, Lee, Seung-Joo, Suh, Hyunsuk, Zhang, Jianming, Kang, Qiaofeng, Zhang, Ting, Westover, Kenneth D., Mandinova, Anna, Lee, Sam W.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4957947/
https://ncbi.nlm.nih.gov/pubmed/27320923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.071
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