Peri-alloHCT IL-33 administration expands recipient T-regulatory cells that protect mice against acute GVHD

During allogeneic hematopoietic cell transplantation (alloHCT), nonhematopoietic cell interleukin-33 (IL-33) is augmented and released by recipient conditioning to promote type 1 alloimmunity and lethal acute graft-versus-host disease (GVHD). Yet, IL-33 is highly pleiotropic and exhibits potent immu...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Matta, Benjamin M., Reichenbach, Dawn K., Zhang, Xiaoli, Mathews, Lisa, Koehn, Brent H., Dwyer, Gaelen K., Lott, Jeremy M., Uhl, Franziska M., Pfeifer, Dietmar, Feser, Colby J., Smith, Michelle J., Liu, Quan, Zeiser, Robert, Blazar, Bruce R., Turnquist, Hēth R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4957164/
https://ncbi.nlm.nih.gov/pubmed/27222477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-12-684142
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