Gene silencing of endothelial von Willebrand Factor attenuates angiotensin II-induced endothelin-1 expression in porcine aortic endothelial cells

Expression of endothelin (ET)-1 is increased in endothelial cells exposed to angiotensin II (Ang II), leading to endothelial dysfunction and cardiovascular disorders. Since von Willebrand Factor (vWF) blockade improves endothelial function in coronary patients, we hypothesized that targeting endothe...

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Publicado en:Sci Rep
Autores principales: Dushpanova, Anar, Agostini, Silvia, Ciofini, Enrica, Cabiati, Manuela, Casieri, Valentina, Matteucci, Marco, Del Ry, Silvia, Clerico, Aldo, Berti, Sergio, Lionetti, Vincenzo
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4957110/
https://ncbi.nlm.nih.gov/pubmed/27443965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30048
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