Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses

Inflammation and endoplasmic reticulum (ER) stress are associated with many neurological diseases. ER stress is brought on by the accumulation of misfolded proteins in the ER, which leads to activation of the unfolded protein response (UPR), a conserved pathway that transmits signals to restore home...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Guthrie, Lauren N., Abiraman, Kavitha, Plyler, Emily S., Sprenkle, Neil T., Gibson, Sara A., McFarland, Braden C., Rajbhandari, Rajani, Rowse, Amber L., Benveniste, Etty N., Meares, Gordon P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4957064/
https://ncbi.nlm.nih.gov/pubmed/27226638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.738021
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