Regulation of transient receptor potential vanilloid 1 expression in trigeminal ganglion neurons via methyl-CpG binding protein 2 signaling contributes tongue heat sensitivity and inflammatory hyperalgesia in mice

BACKGROUND: Pain hypoalgesia has been reported in Rett syndrome patients, a severe neurodevelopmental disorder which can be attributed to mutations in the methyl-CpG binding protein 2 (MeCP2). Here, we examined the role of MeCP2 signaling in tongue heat sensitivity in the normal and inflamed state u...

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Publicado en:Mol Pain
Autores principales: Suzuki, Azumi, Shinoda, Masamichi, Honda, Kuniya, Shirakawa, Tetsuro, Iwata, Koichi
Formato: Artigo
Lenguaje:Inglês
Publicado: SAGE Publications 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956183/
https://ncbi.nlm.nih.gov/pubmed/27030715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1744806916633206
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