Improvement of ENU Mutagenesis Efficiency Using Serial Injection and Mismatch Repair Deficiency Mice

ENU mutagenesis is a powerful method for generating novel lines of mice that are informative with respect to both fundamental biological processes and human disease. Rapid developments in genomic technology have made the task of identifying causal mutations by positional cloning remarkably efficient...

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Udgivet i:PLoS One
Main Authors: Gallego-Llamas, Jabier, Timms, Andrew E., Pitstick, Rose, Peters, Janet, Carlson, George A., Beier, David R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956170/
https://ncbi.nlm.nih.gov/pubmed/27441645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159377
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